Polymorphism of IL-17A related to toxoplasmosis among pregnant and aborted women in Baghdad province
DOI:
https://doi.org/10.5281/zenodo.10307044Keywords:
Interleukin-17A, Toxoplasmosis, IgG, IgMAbstract
The intracellular parasite Toxoplasma gondii, responsible for toxoplasmosis, poses a significant zoonotic threat to both humans and homeothermic animals. Recent findings highlight the pivotal role of T helper 17 (Th17) cells, a subset of CD4+ T cells, in producing the cytokine IL-17A, a key component of the immune response. In this study, 96 blood samples were collected from pregnant and aborted women, with 5 milliliters utilized for Toxoplasma IgG and IgM detection using the VIDAS analyzer. Additionally, 2 milliliters were collected for IL-17A molecular analysis, and the samples were stored at -20°C until required. The investigation uncovered a significant prevalence of the A allele at the homozygous AA genotype in SNP rs2275913 IL-17A. Statistical analysis revealed a noteworthy odds ratio (OR) of 1.7 (0.40-7.3) with a p-value of 0.4 for genotype AA. Notably, allele A occurred at a higher frequency (30%) in the patient cohort with an OR of 1.71 (0.61-4.8) and a p-value of 0.3, contrasting the lower frequency (80%) observed in the control group. In conclusion, the frequency of IL-17A rs2275913 and allele A differed significantly between patients and controls, emphasizing the elevated occurrence of the risk allele A in the patient group.
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